Abstract: The importance of efficiency use of resources in production of any agricultural product cannot be over-emphasized. The study empirically examined the efficiency use of resources among the maize growers in four Local Government Areas of Ekiti State, Nigeria. Descriptive and regression analyses were employed to analyse the data collected with the aid of structured questionnaire from 202 maize farmers. Cobb-Douglas production function was chosen as a lead equation based on economic, econometric and statistical criteria. Descriptive analysis showed that the modal age group for the maize farmers was 41-50 years. It was observed that farmers had fairly large household sizes with an average of 8 people per household. Ninety three percent of the respondents were educated. Also, 74% of the respondents made maize production their primary occupation. Most (81%) of the respondents were small scale farmers. The farmers were faced with quite a number of problems. The regression analysis revealed that land (X₁), family labour (X₂) hired labour (X₃), seeds (X₄) and working capital (X₅) were statistically significant at 1, 5 and 10% level out of the 6 postulated farm inputs. Also, F-value was statistically significant at 1% level of significance. The coefficient of multiple determination (R²) of 0.79 shows that about 79% variations in maize output were caused by variations in the six postulated explanatory variables. When Marginal Value Product (MVP) for each variable was compared to its factor cost, it was revealed that all the farm inputs used by the maize farmers were inefficiently utilized. X₁, X₃ and X₄ were under-utilized while X₂, X₅ and fixed capital (X₆) were over utilized. The return to scale value 1.15 showed that the farmers were operating in the stage one of the production surface. This is the stage where increasing return to scale operates. Finally, some recommendations were made in order to increase the production of maize in Ekiti State and Nigeria at large.