Abstract: Study of problem of expansion of synergetic methodology into economic science and management was offered. We have studied synergetic models and statements of some researchers regarding assessment of enterprises’ operation efficiency. We have analyzed the parameter that is introduced by synergists, namely; system activity, which allowed simultaneously consider all possible quantitative and qualitative conditions and factors at solving the task of efficiency assessment. It has been stated that this parameter reflects cost estimate of intangible assets of the enterprise which are defined as goodwill, brand and production prime costs. It has been detected that Synergetic Model, suggested by the researchers is a non-linear dynamic systems (or non-linear differential equations), which has been well known in mathematics. We have demonstrated an inability of Synergetic Model in terms of forecasting in case of unexpected deviations, i.e., the model does not reflect its destination. It has been stated that some researchers understand synergetic effect as an increase of cash flows at the account of cutting outlays and growth of shares’ market value of merger company (just what takes place in traditional economic evaluation of operation efficiency). Thus, we have revealed the existence of double standards, i.e., all that is called synergetic effect is a cost effect, which may be calculated according to earlier developed calculation models. It has been shown that analyzed synergetic models and statements do not favor solving the main question of the economy science, namely; improvement of efficiency of employment of scarce resources.