Abstract: This study develops, a theoretical framework for the research on impact of personality of knowledge worker on his work with knowledge. Its objective is to expand THE previous researches on knowledge workers, knowledge work and management of knowledge workers. Knowledge workers are major creators of value for their organisations. The major tool and source of their work is their knowledge. Knowledge workers work with both explicit and tacit dimensions of knowledge. One of important questions management of knowledge workers raises is what influences the way how knowledge workers work with their knowledge. The hypothesis is that type of personality is important factor that influences how exactly knowledge worker chooses, uses, creates, shares and distributes knowledge. The main research question is: Does the type of personality of knowledge worker influence his style of work with knowledge? If yes how? The methodology used for the review of the literature was, as usual for this type of theoretical research. Researchers collected, described and evaluated different approaches and different ideas on knowledge workers, knowledge and work with it and personality. The data used are secondary data collected from traditional and electronic media. The study pays attention to both historical approaches and the latest approaches in the field. Methods used for the review of the literature include typical methods of theoretical work, e.g., methods that allow interlinking separated pieces of knowledge like analysis and synthesis, comparison, induction, deduction, abstraction, generalisation and critical thinking.