Abstract: Now a days the leading companies have understood that invisible capitals particularly human resources are among the most significant tools of obtaining competitive advantage and improving organizational productivity. Therefore, these organizations intend to increase the productivity of human resources by implementing work systems with high transparency and prevent negative views among human forces. The main purpose of this research is to analyze the high-performance work system on workforce productivity by considering the moderating role of organizational cynicism. The methodology of the present study is practical in terms of the purpose and it’s a descriptive-survey type of research. The research population consists of managers and workers of Shahid Tondghuyan Petrochemicals. Mass of the research population equals 1220 and on the basis Kukran formula 292 questionnaires were distributed among the sample members of the research. In the present study, the researcher makes use of simple random sampling method. To collect the data questionnaire has been implemented and its reliability has been confirmed by the supervising professor and the experts of the field and also to confirm the reliability Cronbach’s alpha and the results confirmed all aspects of the designed questionnaire. To analyze the obtained data in this research Smart PLS software has been run. The obtained results showed that high-performance work systems have positive and significant effect on human force productivity. On the other hand establishing such systems have a negative impact on cynical views. The results also showed that cynical views have opposite and negative impact on organizational productivity and ultimately the moderating role of organizational cynicism was confirmed at influencing high-performance work systems on human resource productivity. The type of moderation was negative which means the reduction of impact of work systems on human productivity.