Abstract: King Khaled Eye Special Hospital in Riyadh, Saudi Arabia is suffering fromfrequent drug supply shortages in the pharmacy. We conducted this survey to identify the causes of drug supply shortages and to look for solutions to prevent this problemin the KKESH pharmacy. The survey questions were adapted and modified from questions in a study published on the causes of drug supply shortages and their effect on patients; some questions were added to address human factors that lead to drug supply shortages. The first part of the questionnaire collected information on demographics and personal characteristics. The second part of the questionnaire assessed drug supply shortages in the KKESH pharmacy. A five-point Likert scale was used to score the responses. The third and final part of the questionnaire is an open-ended question for participants to suggest solutions according to his/her experience to minimize drug supply shortages in the KKESH pharmacy. There were 41 respondents (100%), due to the small population. Almost all (90.2%) respondents are aware of drug substitutions. Most participants learn a drug is in short supply when it becomes a zero stock (53.7%). The 87.8% of the participants agreed that the lack of computerized alert system for low stock of medications is one of the primary causesfora drug supply shortage in the KKESH pharmacy; the lack of effective communication among pharmacy, pharmaceutical warehouse and purchasing departments is the most common cause of shortage in drugsupplies in the KKESH pharmacy; according to participant’s opinions, 33 out of 41 (80.49% and the mean 4.27) agreed. Fourteen participants suggestedthat good communication among the pharmacy, pharmaceutical warehouse and purchasing departments is important in the case of any shortage in drug supplies.