Abstract: The study aimed to identify the impact of green information system in environmental sustainability, and the diagnosis of a mediator role of the green supply chain in enhancing this effect, the study population consisted of all Jordanian pharmaceutical industry companies, it has been the development ofa questionnaire as a tool to collect data of the study was distribution of (96) questionnaire on the sampling unit, redeem them (92) have been eliminated (3) question naires are not valid for the analysis process, bringing the number of valid question naires for analysis process (89) by (92.7%). The recommendations of the study: is the need for manager’s to understand the nature and the level of importance of environmental sustainability that should distinguish them to deal with the environment a strategic perspective.