Abstract: The purpose of this study was to investigate the relationship between the components of transformational leadership and organizational entrepreneurship from the viewpoint of the employees of the University of Isfahan. This study is of correlation descriptive type. Research population is 313 employees of the University of Isfahan in 2015. The sample size was calculated using the formula of Cochran, 150 employees was selected by stratified sampling in proportion to size. Organizational entrepreneurship has been calculated using standard questionnaires of Rodriguez (2010). The transformational leadership variable was evaluated using transformational leadership questionnaire; it is researcher-made questionnaire. The results showed that there is a significant relation between components of transformational leadership and organizational entrepreneurship. and the correlation coefficient equal to 75% was obtained. The results of regression showed that the components of idealized influence, intellectual stimulation and individual considerations have predictive power for organizational entrepreneurship with multiple correlation coefficient of 70, 74 and 75%. But the component of inspirational motivation does not have the predictive power of organizational entrepreneurship due to low correlation with organizational entrepreneurship and ultimately the totality of structural equations showed that the conceptual model of research has enough fit. According to hypotheses of the research, it can be concluded that managers who apply transformational leadership at the university are more empowered to implementation of organizational entrepreneurship from the viewpoint of university employees.