Abstract: The study was designed to assess the effect of various coagulants on the protective properties of tofu against acetaminophen induced oxidative stress. Tofu was prepared using different coagulants (calcium salt, alum and steep water (effluent of pap produced from maize). The protective ability of tofu was assessed by treating acetaminophen (50 mg/rat/day) stressed rats with the tofu and water ad libitum for 2 weeks. Oral administration of rats fed basal diet with mega dose of paracetamol (50 mg/100 g) caused a significant decrease in the total feed intake (141.8±5.31 g/rats/days), total weight gain (9.1±1.35 g/rats/days), PCV (33±2.60 g L^-1), Hb (10.9±1.48 g L^-1), RBC (4.1±0.91x10⁶ mm²), MCV (66.5±3.65 fl) and WBC (1900±19.49 mm³) compared with those on the basal diet without paracetamol. However, those rats fed with various coagulated tofu with paracetamol had a significant increase in the PCV (34.0-35.5 g L^-1), Hb (11.3±1.50-11.8±1.54 g L^-1), RBC (4.2±0.92-4.8±0.98x10² mm²), MCV (70.5±3.75-74.8±3.87 fl), WBC (2000±20.00-2800±23.66 mm³) and MCH (9.4±1.37-9.8±1.40x10^-12), compared to those fed basal diet with paracetamol. Also, a significant increase of the serum ALP (122±4.93 mg dL^-1), ALT (31±2.49 mg dL^-1) and AST (101±4.49 mg dL^-1) were observed in rats fed basal diet with paracetamol, compared to those fed basal diet without paracetamol. While those fed tofu with paracetamol had significantly lower value in serum AST (94±4.34-80±4.0 mg dL^-1), ALT (30±2.45-26±2.28 mg dL^-1) and ALP (120±4.90-1104.70 mg dL^-1) compared to those fed basal diet with paracetamol. Furthermore, a significant increase in the serum cholesterol (172±5.87 mg dL^-1), LDL (83±4.07 mg dL^-1), HDL (89±4.22 mg dL^-1) and triglyceride (84.3±4.11 mg dL^-1) levels of rats fed basal diet with paracetamol, compared with those fed those fed basal diet without paracetamol while those fed tofu with paracetamol had a significant lower values in serum cholesterol, HDL, LDL and triglyceride, compared to those fed basal diet with paracetamol orally administered.