Authors : Charles Bitamazire Businge, Benjamin Longo-Mbenza, Oladele Vincent Adeniyi, Victor Nzuzi Babeki, Achille Kitambala Kaboka, Moise Mvitu Muaka, Mireille Solange Nganga Nkanga, Christophe Masiala Tsobo, Roland Vangu, Emmanuel Mabiala Diambu and Daniel Ter Goon
Abstract: This study assessed the risk and severity of pre-eclampsia associated with obesity and dyslipidemia in a peri-urban population of Kinshasa Province, Democratic Republic of Congo (DRC). This case control study recruited 200 participants with preeclampsia as cases and 150 age-matched pregnant women without preeclampsia as controls at the LOMO Medical Centre, Kinshasa. Waist circumference, systolic and diastolic blood pressure, carotid intima-media thickness, serum lipids, C-peptide and Homeostasis-Insulin Resistance Index (HOMA-IR) were measured. There was a significant positive correlation between preeclampsia severity and most markers of metabolic syndrome with biologic gradient. The means±SD for controls, participants with mild and severe pre-eclampsia, respectively were: BMI (kg/m2) 22.2±5.5, 24.1±5.7 and 25.6±6.0, p<0.0001; Total cholesterol (mg/dL) 105.0±56.8, 153.6±63.1 and 173.3±60.1, p<0.0001; LDC (mg/dL) 107.3±3.4, 112.2±4.7 and 122.6±3.5, p = 0.006; TNF-α (ng/L)101.8±4.8, 103.1±6.6, 137.7±5.2 p<0.0001; HOMA-IR (mg/dL) 7.3±0.9, 8.3±1.1 and 11.3±0.7, p<0.0001. There was a negative correlation between pre-eclampsia severity and HDL (mean±SD mg/dL) controls: 41.5±3.2, mild pre-eclampsia: 42.4±4.7 and severe pre-eclampsia: 29.4±2.4, p = 0.003. High BMI increases the risk and severity of pre-eclampsia which may increase the risk of subsequent chronic cardio-metabolic diseases in the mothers. Contrary to other studies, LDL was elevated among pre-eclampsia women in the study population.
Charles Bitamazire Businge, Benjamin Longo-Mbenza, Oladele Vincent Adeniyi, Victor Nzuzi Babeki, Achille Kitambala Kaboka, Moise Mvitu Muaka, Mireille Solange Nganga Nkanga, Christophe Masiala Tsobo, Roland Vangu, Emmanuel Mabiala Diambu and Daniel Ter Goon, 2017. Increased Risk and Severity of Pre-Eclampsia among Peri-Urban Women in Kinshasa Province, Democratic Republic of Congo: The Role of Nutritional Transition, Obesity and Dyslipidemia. International Journal of Tropical Medicine, 12: 29-34.