Authors : Jeonghoon Heo , Henry. G. Kattesh , Jules J.E. Dorz , Mary P. Roberts and James D. Godkin
Abstract: In vitro production of corticosteroid-binding globulin (CBG) was evaluated in liver collected from piglets at 3 to 40 days of age and compared to the developmental pattern of plasma levels of CBG. The amount of CBG released per unit weight of liver slices and in circulation was measured using an enzyme-linked immunosorbent assay (ELISA) procedure. Plasma CBG levels were low on days 3 and 10, but significantly (P < 0.05) increased on day 30. The concentration of CBG released from liver slices cultured for 12 hours was higher (P < 0.01) on day 10 than that measured on the other days. These results suggest that plasma CBG levels and the production of CBG by liver may be related to age of the piglet, but there are age-related differences in the profiles of CBG produced by liver tissue and that found in the plasma.
Jeonghoon Heo , Henry. G. Kattesh , Jules J.E. Dorz , Mary P. Roberts and James D. Godkin , 2003. In vitro Liver Synthesis and Plasma Levels of Corticosteroid-binding Globulin (CBG) in the Piglet. Journal of Animal and Veterinary Advances, 2: 82-84.