Abstract: Sildenafil citrate is an orally administered effective treatment for erectile dysfunction; nevertheless administrated in high concentrations produces relaxation of myometrium in pregnant women, thus sildenafil or related molecules may have future potential tocolytic application. In the present review sildenafil mechanism of action, pharmakocinetics and therapeutic use are discussed. Sildenafil is also considered a potent pulmonary vasodilator in pharmacology representing an alternative to neonates during the last month of in utero development. We conclude that studies in animals including metabolic and physiological traits in the fetus and neonates from treated dams with sildenafil in their last third of pregnancy may help to characterize neonate tolerance to asphyxia with posterior application in human perinatology.
P. Sanchez-Aparicio , D. Mota-rojas , R. Ramirez Necoechea , A. Olmos-Hernandez , M. Alonso-Spilsbury , D. Villanueva-Garcia , M.E. Trujillo-Ortega and R. Hernandez-Gonzalez , 2007. Systemic Effects of Sildenafil Citrate on Pregnancy and Perinatal Periods. Journal of Animal and Veterinary Advances, 6: 267-271.