Authors : E.R. Al Kennany and S. Muneer Al Badrany
Abstract: This research was conducted to explore the ability of Toxoplasma gondii, that isolated recently from backyard chickens in Mosul city- Iraq, to induce oxidative stress and searching of any atheromatous lesions that developed in aorta of experimentally infected broiler chickens. The results elucidated a lipid peroxidation status in aortic and heart tissues of infected broilers. This status characterized by a significant increasing in Malondialdehyde (MDA) level and a significant decrease in glutathione concentrations of that tissues. Histological inspection of these tissues revealed the presence of tachyzoit and tissue cyst. Furthermore, histological picture of these aortas shows, hypertrophy of the endothelial lining as well as hypertrophy and proliferation of vascular smooth muscle cells from media to ward aortic intima; and accumulation of lipid vacuole concomitant with foamy cells in both media and intima. In conclusion, this study may revealed the capability of the Toxoplasma gondii for induction a similar pathophysiological alterations in both mammals and avies.
E.R. Al Kennany and S. Muneer Al Badrany , 2007. Pathological Study on the Capability of Toxoplasma gondii to Induce Oxidative Stress and Initiation a Primary Lesion of Atherosclerosis Experimentally in Broiler Chickens . Journal of Animal and Veterinary Advances, 6: 938-942.