Authors : A. Fatih Fidan , Huseyin Enginar , I. Hakki Cigerci , S. Elif Korcan and Ayse Ozdemir
Abstract: The present study, was designed to determine the possible protective effects of Spinacia oleracea L. extract (S.E) and Aesculuc hippocastanum L. extract (AE) against oxidative tissue damage induced by radiation as well as examinig their in vitro antibacterial potential. The animals were divided totally 4 groups as Control (C), Radiation (R), S.E Extract + Radiation (SER) and AE Extract + Radiation (AER) group. AER and SER groups were also separated to 2 subgroups as SER 1, SER 15, AER 1 and AER 15. C group was administered by 1 mL 0,9 % saline every other day during 20 days. The R group rats were received 1 mL q 0,9% saline every other day i.p. and other day 0.5 Gy radiation during 20 days (n = 10). The other groups, SER and AER were administered by 50 mg kg 1 i.p. S.E and AE extract every other day and other day 0.5 Gy radiations, respectively for 20 days. At the end of experimental period, the animals sacrificed by anesthetizing at 1 (group-C, R, SER 1 and AER 1) and 15 days (group-SER 15 and AER 15) postirradiation. Malondialdehyde (MDA) and reduced Glutathione (GSH) levels in tissues and in vitro antimicrobial activity in the plant extracts were determined. The results indicate that S.E and AE treatment decreases the tissue oxidative stress in irradiation-induced oxidative tissue damage by maintaining the GSH recycling activity and free radical scavenging potential. Moreover, our results demonstrate that, in animals exposed to irradiation,S.E and AE could provide great advantages against to systemic infection from endogenous and exogenous organisms increased after exposure to ionizing radiation. Consequently, the natural compound found in S. oleracea and A. hippocastanum including antioxidants, antimicrobials and other phytonutrients, substantially could be protect the tissue from radiation damage and its complications.
A. Fatih Fidan , Huseyin Enginar , I. Hakki Cigerci , S. Elif Korcan and Ayse Ozdemir , 2008. The Radioprotective Potential of Spinacia oleracea and Aesculuc hippocastanum Aganist Ionizing Radiation with Their Antioxidant and Antimicrobial Properties. Journal of Animal and Veterinary Advances, 7: 1528-1536.