Authors : Samia A.A. Hassan , Sana A.I. Shaddad , A.K. Muddathir , I.B. El-Tayeb , A.O.M. Nour , M.H. Al-Nazawi and A.M. Homeida
Abstract: The pharmacokinetics of long-acting Oxytetracycline (OTC) formulation (Alamycin-LA) was studied after intramuscular (IM) route at a dose of 1 mg kg 1 body weight to fifteen healthy desert sheep. The mean Cmax values of 74.8�13.22 �g mL 1 was after 0.9�0.13 h, the mean distribution phase was 2.0�0.4 h and the apparent elimination half-life was 126�23 h. The volume of distribution (Vd) was found to be 67.933�4.88 L. The area under the curve (AUC0240) and the area under concentration-time curve (AUMC) were 2530.26�203.3, 242522.2�48504.5 �g/ml/h2, respectively. The total body clearance (cl ) was 373.63�18.9 mL h 1 while the mean resident time (MRT) was 90.61�13.8 h.
Samia A.A. Hassan , Sana A.I. Shaddad , A.K. Muddathir , I.B. El-Tayeb , A.O.M. Nour , M.H. Al-Nazawi and A.M. Homeida , 2008. Pharmacokinetics of Long-Acting Oxytetracycline Formulation Following Intramuscular Administration in Desert Sheep. Journal of Animal and Veterinary Advances, 7: 433-436.