Authors : Halil Selcuk Biricik, Nihat Sindak, Cengiz Ceylan and Ali Hayat
Abstract: This study was designed to compare the effects of propofol and thiopental on Intraocular Pressure (IOP) in dogs. In the study, twenty healthy dogs were used as material. Nonpremedicated cases were divided into two groups of 10 dogs each. Group I dogs were induced with 7 mg kg-1 of propofol, group II dogs induced with 20 mg kg-1 of thiopental prepared as 2.5% solution. IOP was measured before and 5 min after induction of anesthesia. Both anesthetics decreased IOP significantly (p<0.001) and falling ratios were similar between the two groups. Heart and respiratory rate, rectal temperature were recorded before and 10 min after induction of anesthesia. While the heart rate increased during anesthesia in group II dogs, there were no significant differences at other measured clinical parameters in both groups. In group I, recovery vas comfortable. However, recovery was violent and noisy in 5 dogs of group II. As a result both drugs decreased IOP at similar ratios. However, with regard to few side effects, it was concluded that the use of propofol might be more suitable in ophtalmic operations.
Halil Selcuk Biricik, Nihat Sindak, Cengiz Ceylan and Ali Hayat, 2010. A Comparison of the Effects of Propofol and Thiopental on Intraocular Pressure in Dogs. Journal of Animal and Veterinary Advances, 9: 1160-1163.