Authors : Ayse Topal, Hulya Bilgin, Cuneyt Ozakin, Suna Gedikoglu and Nihal Y. Gul
Abstract: Extrinsic contamination of propofol is thought to be a source of postoperative sepsis. Researchers studied growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans in propofol, thiopental and in a 1:1 propofol-thiopental mixture. All microorganisms were taken from standard stock cultures. Half of the samples were incubated at 20°C and the rest were stored at 4°C for 120 h. Growth of microorganisms in each solution was compared by counting the number of the Colony-Forming Units (CFUs) at 0, 3, 6, 24, 72 and 120 h. Propofol supported the growth of all four microorganims at both temperatures. In contrast, thiopental and the 1:1 propofol-thiopental mixture exhibited markedly bactericidal properties on E. coli, C. albicans and P. aeruginosa and bacteriostatic effect on S. aureus.
Ayse Topal, Hulya Bilgin, Cuneyt Ozakin, Suna Gedikoglu and Nihal Y. Gul, 2010. Growth of Staphylococcus aureus, Candida albicans, Escherichia coli and Pseudomonas aeruginosa in Propofol, Thiopental and a 1:1 Propofol-Thiopental Mixture. Journal of Animal and Veterinary Advances, 9: 1432-1435.