Abstract: Interferon-gamma (IFN-γ) is essential for modulating immune responses in mammals. In this study, one Single Nucleotide Polymorphism (SNP) of porcine IFN-γ (Po IFN-γ) was identified at position 1165 in intron I (deletion or insertion of A). Blood samples from 306 piglets were collected. The blood parameters, antibody levels of PRRSV, CSFV and PRV were measured for all piglets at 1, 17, 32 days ages, respectively. In addition, 11 growth traits were also measured for all pigs. Association analysis between the IFN-γ- + 1165 + A polymorphism and antibody levels, blood parameters and growth traits were conducted. Significant effects of the SNP genotype was observed on 1st day PRV Ab, muscle depth (p<0.01), 1st day CSFV Ab, 32nd day MCHC, hucklebone width and daily gain from birth to 100 kg (p<0.05). Thus, the single nucleotide deletion polymorphism in IFN-γ could be an important genetic marker for both immune response and growth traits and can be potentially used in pig breeding.
Nu-Nu Sun, Hui-Yong Chen, Xiang-Dong Liu, Ming-Di Fang, Shu-Hong Zhao and Zhen-Fang Wu, 2010. A Polymorphism in the IFN-γ Gene is Associated with Immune Response and Economic Traits in Landrace Pig. Journal of Animal and Veterinary Advances, 9: 1441-1444.