Authors : Sefa Lok, Erdal Tasgin, Nagehan Demir and Mehmet Ozdemir
Abstract: The purpose of the research is to define the effects of testosterone on heart, liver, kidney and some chemical values in male rats during puberty. In the research 16 Sprague dawley rats, 50 days old were used. The rats were divided into two equal groups. The first group was administrated testosterone, diluted with olive oil, 5 mg kg-1 (SID) subcutaneously for 10 weeks 5 days each week. The second group was only given olive oil. At the end of the 10th week blood samples were taken. Serum creatine kinase, creatine kinase-MB, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, triglyceride, cholesterol, high density lipoprotein, amylase, total protein, albumin and calcium were measured with an auto-analyzer. It was determined that while testosterone application in male rats led to increase on the serum CK-MB, CK and AST levels (p<0.05), it caused decreases on the total protein, albumin, calcium and creatinine (p<0.05). As a result, it can be stated that long term testosterone implication during puberty may lead to heart and liver defects at early ages.
Sefa Lok, Erdal Tasgin, Nagehan Demir and Mehmet Ozdemir, 2010. Long Term Used Testosterone May Cause Heart and Liver Damage. Journal of Animal and Veterinary Advances, 9: 2343-2345.