Authors : Yasemin S. Karafakioglu and Recep Aslan
Abstract: The present study was designed to determine the possible protective effects of taurine against oxidative damage induced by nonylphenol in rats. The rats were divided into 5 groups each containing 8 Wistar-albino male rats rats: Control group (C) by standart rat feed, Taurine group (T) by standart rat feed + 3% taurine (v w-1) in drinking water, Nonlyphenol group (NF) by standart rat feed + 50 μg kg-1 diet Nonlyphenol, Nonlyphenol + Taurine group (NFT) by standart rat feed + 50 μg kg-1 diet Nonlyphenol + 3% taurine (v w-1) in drinking water and Alchol group (A) by standart rat feed + 50 μL kg-1 diet alchol were fed ad-libitum for 30 days during the study. Malondialdehyde (MDA), reduced Glutathione (GSH) levels, superoxide dismutase activity and Nitric Oxide (NOx) were determined in blood. MDA levels in blood of the rats significantly increased in NF and A group compared to control, T and NFT groups (p<0.05). On the other hand, the blood GSH concentrations significantly decreased in NF group compared to control and other groups (p<0.001). The SOD activities in blood significantly decreased in NF and A groups compared to control, T and NFT groups (p<0.01). The plasma NOx levels in NF group significantly decreased compared to control and other groups (p<0.01). Consequently, taurine could be used as a potential antioxidant aganist nonylphenol toxication with its antioxidant properties.
Yasemin S. Karafakioglu and Recep Aslan, 2010. Taurine Prevents Nonylphenol-Induced Oxidative Stress in Rats. Journal of Animal and Veterinary Advances, 9: 37-43.