Authors : Sadiye Kum, Mustafa Sandikci, Ulker Eren and Nursal Metin
Abstract: The aim of this study was to investigate frequency of fatty liver and kidney of the developing and adult rats exposed to formaldehyde (HCHO) or xylene or a combination of these two agents. Ninety six female Sprague-Dawley rats were used in this study. At the beginning of the experiment, the rats were randomly divided into four groups with following ages. The animals were exposed to gases of technical xylene (300 ppm), HCHO (6 ppm) or technical xylene + HCHO (150 +3 ppm), 8 day-1 for 6 weeks. After the exposure period, the rats were anesthetized with xylazin-ketamine intraperitoneally. Animals were sacrificed by cervical dislocation. The weight of liver and kidney were measured. Left kidney and liver obtained from each rat. Sections were stained HδE, for the histopathologic investigation and sections stained by the Oilred O and Sudan Black stains for the demonstration of neutral triglycerides. At the end of the study period, the fat deposition observed in the liver and kidneys of the experimental groups was in the form of fine granular fats. This study showed that inhalation of HCHO, xylene or its combination (xylene + HCHO) lead to deposition of adipose tissue in the liver and kidneys.
Sadiye Kum, Mustafa Sandikci, Ulker Eren and Nursal Metin, 2010. Effects of Formaldehyde and Xylene Inhalations on Fatty Liver and Kidney in Adult and Developing Rats. Journal of Animal and Veterinary Advances, 9: 396-401.