Journal of Animal and Veterinary Advances

Year: 2011
Volume: 10
Issue: 16
Page No. 2172 - 2175

Expression Analysis of HIF-1α and HIF-2α Genes in Tibetan Chicken under Normoxia and Hypoxia

Authors : Y.Z. Yang, Y. Bai, X.X. Dong, J.B. Zhang and M. Fang

Abstract: Tibetan chicken is one of those chicken breeds that could adapt to high altitude and low O2 tension environment; it owes an integrative genetic mechanism for hypoxia adaptability compared to lowland chicken breeds. HIF-1α and HIF-2α are the central factors playing important roles in maintaining organisms’s oxygen homeostasis. In this study, the expression of HIF-1α and HIF-2α genes were investigated by Real Time-PCR in Tibetan chicken and Dwarf chicken embryo brain tissue under normoxia (21% oxygen concentration) and hypoxia (13% oxygen concentration). The results showed that Tibetan chicken always had lower mortality than Dwarf chicken during the incubation. We also detected higher HIF-αs expression at the late of incubation (18th day) compared with that at 12th day in all tested samples; we further obtained the expression pattern of HIF-αs genes in dead embryos was opposite to that in live embryos.

How to cite this article:

Y.Z. Yang, Y. Bai, X.X. Dong, J.B. Zhang and M. Fang, 2011. Expression Analysis of HIF-1α and HIF-2α Genes in Tibetan Chicken under Normoxia and Hypoxia. Journal of Animal and Veterinary Advances, 10: 2172-2175.

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