Authors : Kamran Kaveh, Rashid Ibrahim, Md. Zuki Abu Bakar and Tengku Azmi Ibrahim
Abstract: Mesenchymal Stem Cells (MSC) are multipotent non-hematopoietic progenitor cells with an extensive proliferation potential and ability to differentiate into various cell types including osteoblasts, chondroblasts, myocytes, adipocytes and neurocytes. MSC is a cell of bone marrow population that plays a key role in bone marrow homeostasis and regulates the maturation of both hematopoietic and non-hematopoietic cells. Mesenchymal stem cells have been emerged in promising therapeutic modality for tissue regeneration and repair. Treatment of graft versus host disease, heart regeneration following infarction, cartilage and bone repair and treatment of osteogenesis imperfecta are only few therapeutic application of MSC. Tissue engineering in recent years opened a new frontier to replace the affected tissue by MSC assistance. Mesenchymal stem cell seems to be the future powerful tool in therapeutic application of regenerative medicine in repairing and replacing the impaired organs. The main aim of current review is to have a more precise look to MSC, its proliferation and differentiation potentials, therapeutic application and bone tissue engineering.
Kamran Kaveh, Rashid Ibrahim, Md. Zuki Abu Bakar and Tengku Azmi Ibrahim, 2011. Mesenchymal Stem Cells, Osteogenic Lineage and Bone Tissue Engineering: A Review. Journal of Animal and Veterinary Advances, 10: 2317-2330.