Abstract: Primphos a synthetic organophosphate poisons are the property of insecticide. These toxins as insecticides in agriculture and medicine for animals and the destruction of ectoparasites can be used. Studies have shown that Primphos creation seizure effects in different animals. Amlodipine, dihydropyridine calcium channel blockers, widely used for treatment of cardiovascular diseases. Studies have shown that the calcium channel blockers are anticonvulsant effects in different animal models. The aim of this study was to determine the effect of Amlodipine on Primphos-induced seizures in mice. In this experiment, the animals were received different doses of Amlodipine (2.5, 5, 10, 20 and 40 mg kg^-1) intraperitoneally 30 min before intraperitoneal injection of Primphos (500 mg kg^-1). After Primphos injection, clonic and tonic seizures and death was investigated. Results showed that Amlodipine dose dependently reduced the severity of Primphos-induced seizures so that Amlodipine dose 20 and 40 mg kg^-1, respectively the lowest (p<0.05) and highest (p<0.01) had anticonvulsant effects. The anticonvulsant activity of Amlodipine suggests that possibly due to antagonistic effect on voltage-dependent calcium channel.