Authors : Zhao Chun-Lin, Wu Run, Li Fa-Di, Liu Lei, Zhang Xiao-Li and Wang Chuan
Abstract: In order to investigate the possible relationship at the transcriptional level between CLPG and PRNP in sheep and the description of relationship of sheep reproductive with different PRNP genotype, the expression of CLPG gene in different tissues and different PRNP genotypes was determined using fluorescence quantitative PCR. The results showed CLPG has a tissue-specific gene expression as CLPG gene expression in cerebellumwas significantly higher than other organizations. However, genotyp specific expression was not detected in spite of the p-value in some tissues almost close to 0.05. Therefore, the researchers speculate that the expression of CLPG in different PRNP genotype may exist but the final conclusion need to be proved with the other genes which are related to growth trait in more different PRNP genotypes.
Zhao Chun-Lin, Wu Run, Li Fa-Di, Liu Lei, Zhang Xiao-Li and Wang Chuan, 2011. Expression of Sheep CLPG in Different PRNP Genotypes. Journal of Animal and Veterinary Advances, 10: 2926-2929.