Authors : Xiaoyu Yan, Guang Yang, Xiangguo Cheng, Cheng Liang, Yimin Chai, Congfeng Luo and Bingfang Zeng
Abstract: The present research is to observe the effect of Extracorporeal Shock Wave Therapy (ESWT) on neovascularisation and expression of Ang-1, Ang-2 and VEGF in promoting excisional wound healing in diabetic rat model. Excisional wounds were made in STZ-induced diabetic rats and randomly divided into treatment, diabetic control and normal control groups. Wound in treatment group was treated by ESWT with 0.11 mJ/mm2, 1.5 Hz and 500 pulses 1 day post-wounding. In diabetic and normal control groups, wound received no ESWT. Wound closing rate and healing time were calculated. Granulation tissue, neovascularization and expression of Ang-1, Ang-2 and VEGF in wound tissue from different groups were compared. The results showed that healing of diabetic wound was poor and expressions of angiopoietin-1, angiopoietin-2 and VEGF were altered as compared with normal wound. After ESWT however, microvessels and granulation tissue were increased and the expressions of VEGF and Ang-1 were increased while Ang-2 expression was decreased, respectively. In conclusion, abnormal expression of Ang-1, Ang-2 and VEGF may contribute to poor neovascularization and impaired healing in the diabetic wound and topical ESWT application can improve diabetic wound healing by enhancing neovascularisation and altering the expression of Ang-1, Ang-2 and VEGF. ESWT may represent a feasible method for improving the impaired healing of diabetic wound.
Xiaoyu Yan, Guang Yang, Xiangguo Cheng, Cheng Liang, Yimin Chai, Congfeng Luo and Bingfang Zeng, 2012. Extracorporeal Shock Wave Therapy Improves the Impaired Neovascularization in Diabetic Wound Healing via Altering the Expression of Angiopoietin-1 and Angiopoietin-2. Journal of Animal and Veterinary Advances, 11: 3160-3168.