Authors : Ji-Yu Zhang, Xu-Zheng Zhou, Bing Li, Ya-Jun Yang, Xiao-Juan Wei, Jian-Rong Niu, Jian-Yong Li, Jin-Shan Li and Xi-Wang Liu
Abstract: The purpose of this study was to evaluate the treatment efficacy of 1% doramectin injection against nematode in swine infected naturally in China and determine dosage regimen of doramectin in swine. A controlled clinical study was conducted on 200 swine infected with nematode naturally in Lanzhou. The tested groups included doramectin 400, 300 and 150 μg kg-1 by IM, ivermectin 300 μg kg-1 by SC as drug control group and blank control group. The results showed the efficacy against nematode of high dosage doramectin (400 μg kg-1) was significantly difference from middle and low dosage group (p<0.05) and was significantly difference from control ivermectin group (p<0.01). The persistent period of nematocidal with high, middle and low dosage were 28, 28 and 21 days, respectively. The body weight gain of high, middle dosage doramectin and ivermectin group were significantly difference from the low dosage doramectin and untreated control (p<0.05 and p<0.01). So, the recommended dosage regimen of doramectin against swine’s nematode was 300 μg kg-1 body weights by IM for once administration of medicine.
Ji-Yu Zhang, Xu-Zheng Zhou, Bing Li, Ya-Jun Yang, Xiao-Juan Wei, Jian-Rong Niu, Jian-Yong Li, Jin-Shan Li and Xi-Wang Liu, 2012. Therapeutic and Persistent Efficacy of Doramectin Against Nematode in Swine Infected Naturally in China. Journal of Animal and Veterinary Advances, 11: 4684-4688.