Authors : ChunLei Song, XiuXing Wang, Xuguang Wang, Xueshan Ma, Jun Zhang, BeiBei Gao and Honglin Liu
Abstract: GGPPS is a member of prenyl transferase family catalyzing the synthesis of GGPP (Geranylgeranyl diphosphate) from Farnesyl diphosphate (FPP) and Isopentenyl diphosphate (IPP). Using cre/loxp system, researchers got oocyte specific knockout ggpps mice. Mutation of ggpps resulted in abnormality of follicular development, granulosa cell premature luteinization, theca cell hypertrophy and multi-oocyte follicles. Interaction of oocyte and granulosa cell was also changed. Oocyte-specific knockout of ggpps mice was acquired. Follicles grew abnormally in ggpps mutation mice. Interaction of oocyte and granulosa cell was also changed.
ChunLei Song, XiuXing Wang, Xuguang Wang, Xueshan Ma, Jun Zhang, BeiBei Gao and Honglin Liu, 2013. Abnormal Follicle Development in GGPPS Conditional Knockout Mice. Journal of Animal and Veterinary Advances, 12: 323-329.