Authors : Jianzhen Lv, Zijie Wang, Li Zhang, Hai-Lian Wang, Yuande Liu, Chunyang Li, Jiagang Deng, Yi-Wang and Jin-Ku Bao
Abstract: Mangiferin, a C-glucosylxanthone (1, 3, 6, 7-tetrahydroxyxanthone-C2-β-D-glucoside) purified from plant sources was shown to have in vitro growth-inhibitory and apoptosis-inducing activity against MCF-7 cells and it also possessed anti-tumor property on MCF-7 xenograft mice in vivo. Mangiferin triggered G2/M phase cell-cycle arrest via down-regulating cdc2-cyclinB1 singling pathway and induced apoptotic cell death through inhibiting PKC-NFκB pathway in human breast carcinoma MCF-7 cells. In addition, mangiferin had anti-cancer effects in vivo and it could decrease the volume and weight of subcutaneous tumor mass obviously as well as expanded lifespan of xenograft mice. With the molecular mechanisms of mangiferin-induced anti-tumor activities were gradually clarified, traditional Chinese medicine would become potential anti-neoplastic drugs in future cancer therapeutics.
Jianzhen Lv, Zijie Wang, Li Zhang, Hai-Lian Wang, Yuande Liu, Chunyang Li, Jiagang Deng, Yi-Wang and Jin-Ku Bao, 2013. Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both in vitro and in vivo. Journal of Animal and Veterinary Advances, 12: 352-359.