Authors : Seigo Itoh, Maiko Watabnabe, Sachiko Arai, Fujiko Sunaga and Sugita- Konishi
Abstract: The emetic toxicities of deoxynivalenol and its acetyl derivatives were examined using house musk shrews (Suncus murinus). Emesis was observed after the oral administration of these toxins at doses ranging from 0-40 mg kg-1 B.W. The Effective Dose (ED) causing emesis was calculated using the Probit Method. The ED 50 of deoxynivalenol, 3-acetylnivalenol and 15-acetylnivalenol was 3.85, 0.87 and 8.85 mg kg-1 B.W., respectively. The results show that the emetic toxicity of 3-acetylnivalenol is 10 times higher than that of deoxynivalenol or 15-acetyl deoxynivalenol. Even though, acetyl deoxynivalenol has been determined to exhibit equivalent toxicity to deoxynivalenol by the FAO/WHO Joint Food Additives Committee, the different responses of acute emetic toxicity should, therefore be taken into account.
Seigo Itoh, Maiko Watabnabe, Sachiko Arai, Fujiko Sunaga and Sugita- Konishi, 2013. A Comparison of the Emetic Toxicity of Deoxynivalenol and Acetyl Deoxynivalenol in House Musk Shrews (Suncus murinus). Journal of Animal and Veterinary Advances, 12: 718-720.