Authors : Jie Liu, Hong Gao, Mingju Fu and Xiaoqing Miao
Abstract: Objective to explore the influence and possible mechanism of bee venom compound preparation Bao Yuan Ling on chronic heart failure with different dosages (1.00, 1.25, 1.50, 1.75 and 2.00 mg kg-1) the results of this study provided important experimental basis for the clinical application of heart failure. The effects of Bao Yuan Ling on model rats with chronic heart failure induced by doxorubicine were explored and measured using the results of serum physiological indexes, organ coefficient and pathological sections of the apex part of heart. Compared with model group, heart failure related indexes level of BNP, MYO/MB, CK-MB and MDA in serum of BYL groups were significantly decreased while TNF-α and GSH-Px increased significantly (p<0.05). No significant organ coefficient changes were induced by the treatment with BYL while dexrazoxane revealed some myocardial hypertrophy effects on heart. Histopathology examination showed changes at myocardial cell level (intercellular substance fibrosis, inflammation infiltration and cell stained) of rats treated with BYL and dexrazoxane at week 6. Moreover, drooping vigor and dilute defecation were relieved in the rats of BYL groups compared with model group. BYL inhibited the progress of chronic heart failure effectively which are superior to the clinic drug dexrazoxane with the optimal dose of 1.50 mg kg-1.
Jie Liu, Hong Gao, Mingju Fu and Xiaoqing Miao, 2014. Therapeutical Efficacy of Bee Venom Compound Preparation Bao Yuan Ling on Rats with Chronic Heart Failure. Journal of Animal and Veterinary Advances, 13: 801-806.