Authors : N.H. Mohammed, Mohamed I. Mostafa and A.Y. AL-Taher
Abstract: New naringenin derivatives bearing halogen moiety (1-6) were designed and synthesized. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. The in-vitro antimicrobial activity of the obtained compounds has been evaluated. All new analogues tested show inhibitory activity against microorganisms under investigation, the most potent compounds are 1-4. The rest of compounds show nearly same antimicrobial activity as ciprofloxacin reference drug used in this study. The new analogues showed also augmentation effect when used together with ciprofloxacin.
N.H. Mohammed, Mohamed I. Mostafa and A.Y. AL-Taher, 2015. Augmentation Effects of Novel Naringenin Analogues and Ciprofloxacin as Inhibitors for Nora Efflux Pump (EPIs) and Pyruvate Kinase (PK) Against MRSA. Journal of Animal and Veterinary Advances, 14: 386-392.