Authors : Fahad Abdullah Al-Hizab, Mohammed Salem Moqbel and Seif Mustafa Barakat
Abstract: The study aimed to evaluate the pathological, haematological and biochemical effects of various levels of dietary Momordica charantia (MC) in male Wistar rats. Momordica charantia (MC) is claimed to have several medicinal properties and is used as a traditional medicine for the treatment of a wide variety of disorders. The fruits of MC was fed to rats at 2, 5 and 10% of the standard diet for a period of 3 months. Administration of MC fruits at 2 and 5% was not toxic to rats. However, focal cellular swelling and individual cell necrosis of hepatocytes as well as degenerative changes in the renal tubules associated with interstitial nephritis were observed in rats fed with a diet containing 10% MC. These histopathological changes were accompanied clinically by alteration of serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkalin Phosphatase (ALP), BUN, creatinine and uric acids. No significant changes were observed in hematological values in all groups.
Fahad Abdullah Al-Hizab, Mohammed Salem Moqbel and Seif Mustafa Barakat, 2017. Pathological Studies of Various Levels of Dietary Momordica charantia on Wistar Rats. Journal of Animal and Veterinary Advances, 16: 43-47.