Abstract: Worldwide reactions to global warming and ozone depletion have led to social responses and legislature measures, which have serious implications for refrigeration and associated industries. Some gases (called Refrigerants) used in the refrigeration industries were sported as contributing factor to this atmospheric degradation. In phasing out these gases alternatives were sought as replacement. Researches are going on, on the thermodynamics and physical properties as well as ozone depletion potentials of these alternatives, but no much attention had been paid to the control of moisture and other containments in these alternative Refrigerant systems. This study examines the moisture solubility in R-12 and one of its established alternatives, namely R-134a. The result for R-12 was compared with an existing data and the deviation was within 20%. The moisture solubility in both R-12 and R-134 follows similar trend at higher temperatures but there is a serious deviation at sub-zero temperature. Looking at the trend of solubility curves, models for predicting moisture solubility in both refrigerants were predicted.