Abstract: The study reveals the essence of the region’s innovation infrastructure as a factor in increasing the efficiency of industrial enterprises. The relevance of the topic is due to the fact that the path of innovative development of industrial enterprises in the Russian Federation based on knowledge, on the change in the economic structure in favor of high-tech industries to increase human capital becomes the only possible way of development in the modern economics. Today, innovation is a component of the business process for companies that are focused on the preservation and strengthening of its position in the markets, especially in the long term. Moreover, innovation is based not only on inventions but on the efficient utilization of resources resulting from scientific and technological progress. The study concludes that the functioning of a modern tool of management in the conditions of growing changes in the external environment acts as a methodology of infrastructural development. The choice of directions and defining the scope of infrastructure development that takes place within the association of industrial enterprises are of the particular importance. The need for innovation in the field of infrastructure solutions plan arises when independent activities related to innovation activities can not achieve their goals. The winner is the company that is able to determine the time, place and subjects of association. Therefore, an adequate regulation of the relationship of enterprises engaged in innovation is the key of success in providing innovative economy. This focus of the new economic thinking requires a fundamental revision of the methodological approach used and the applied methodological tools. The problem of the Russian economy transition on an innovative path of development has been very relevant in the pre-crisis period and remains the same nowadays. It is impossible to overcome the country’s dependence on conditions in the world without handling this problem, especially in the oil market. Active policy of innovative development of the economy must not take second place to fight the crisis. Only innovative renewal of fixed capital and the introduction of new technologies in the production of goods are able to provide a valid output of the economy from the stage of the crisis on the upward trajectory of its functioning and development.