Authors : Sanam Ayub, Muhammad Yaqub Khan and Qadir Bakhsh
Abstract: The Hypothalamic Pituitary Adrenal (HPA) system operates as complex feed forward and feed-back control system whose main purpose is to regulate wide variety of bodily processes, under basal physiological conditions or during stress by regulating the plasma levels of corticosteroids secreted from adrenal glands. The Hypothalamic Pituitary Adrenal (HPA) axis is a biological system connecting three areas in the body by mainly three hormones, Corticotrophin Releasing Hormone (CRH) Adreno Corticotrophin (ACTH) and Cortisol. The HPA Axis was simulated using non-linear equations modeled for important phenomena and the euler and RK-4th order methods were also used. By using the simulink, non-linear equations were also solved and it was concluded that the results are useful for a simulation of resilience in human.
Sanam Ayub, Muhammad Yaqub Khan and Qadir Bakhsh, 2017. R-K 4th Order Mathematical Model of the Hypothalamic-Pituitary-Adrenal Axis Validation with MATLAB Simulation. Journal of Engineering and Applied Sciences, 12: 5666-5671.