Abstract: The study pursues to investigate the effect of HR function on job satisfaction. In particular employee centered culture is expected to moderate the relationship. A corporate panel survey data are used to test the hypotheses. The data included 500 firms representing manufacturing, banking and non-banking service industries. After excluding banking and non-banking service firms, the final sample was composed of 369 manufacturing firms. Prior to proceeding hypothesis testing, factor analysis was conducted. To test the research hypotheses, this study utilized several regression analyses. The results of this study indicate that HR function is positively related to job satisfaction. This positive impact suggests that if HR department participates on decision-making related to business strategy formation and contribute business performance, employee become more satisfied with their job or organization. Thus HR department influence strategic dictions which top management team including CEO design and implement to achieve business goals and sustain its success. The result of this study indicated that the relationship between HR function and job satisfaction is moderated by employee-centered culture. Favorable perception of organizational culture from employee’s experience on work policies, practices, climates, communication and relations among members strengthened the relationship between two variables. When HR functions fit other systems and culture, the effects are enhanced.