Authors : Masrina Mohd Nadzir, Siti Farhana Hisham and Nur Syahirah Adibah Parkir
Abstract: The objective of this study was to evaluate the effects of addition of membrane additives, cholesterol (chol) with further molecular charges modification using Dicetylphosphate (DCP) and Stearylamine (SA) on stability of curcumin niosomes. Niosomes with entrapped curcumin were prepared by thin-film hydration method. This vesicular drug carrier was constructed with mixture of non-ionic surfactants, Span 60/Tween 60 with addition of various ratios of chol. Further modification to niosomes was conducted by addition of DCP and SA. The niosomes were then characterized in terms of morphology, vesicle size, entrapment efficiency and stability upon storage. The results show that niosomes with ratio of surfactants to chol 1:1 have the highest curcumin entrapment efficiency and the largest vesicle size distribution (136-186 nm) compared to the other samples. On the other hand, the lowest content of chol (ratio 5:1) produced the smallest size distribution of particles ranging between 129-181 nm. Niosomes of ratio 1:1 have the highest entrapped curcumin (97.72%) after 7 days storage, indicating best stability compared to samples of other formulations. The addition of charging additives, DCP and SA did not have any effect in maintaining the stability of curcumin niosomes during short-term storage. The data show that curcumin can be successfully formulated in niosomes and the addition of single additive, chol is sufficient for maintaining the stability of curcumin niosomes constructed from mixture of Span 60 and Tween 60.
Masrina Mohd Nadzir, Siti Farhana Hisham and Nur Syahirah Adibah Parkir, 2017. Effects of Cholesterol and Charging Additives on Stability of Curcumin Niosomes. Journal of Engineering and Applied Sciences, 12: 8537-8541.