Abstract: This study is finding out 4 kinds of extract’s total amount of flavonoids and polyphenols these extracts are obtained by drying Smilacis Glabrae Rhizoma as 80% ethanol a solvent, extraction temperature 30, 70°C and distilled water as a solvent and extraction temperature 30, 100°C and confirming anti-aging active through antioxidant and whitening effect. As a result, the total polyphenol and total flavonoid content also extract ethanol 70°C each of 75.86, 2.38 mg/g showed the highest antioxidant effect. Tyrosinase inhibitory activity, 80% ethanol 30°C is the highest as 40.57%. From the above results, Smilacis Glabrae Rhizoma’s extracts has tyrosinase inhibitory activity, effectiveness of antioxidant and since, it showed various effects in clinical practice, we confirmed that, it has the potential applications as natural cosmetics material.