Abstract: Statistical data show that Acquired Immune Deficiency Syndrome (AIDS) is prevalent in every State of Nigeria. The prevalence level varies between 1.6% in Ekiti State and 10% in Benue State. Among the major causes of the disease in Nigeria are sexual intercourse with persons already infected, contact with the blood of infected persons and infection of babies by mothers carrying the HIV virus. Most Nigerians are religious. They practise Islam, Christianity or the Traditional Religion. In view of this, Government sometimes resorts to the use of religion to mobilize citizens for civic duties. This study calls for taking advantage of the religious life of Nigerians, especially Muslims among them, to look into the possibility of using the teachings of Islam to stem the tide of the spread of the disease. Of course, there are challenges in this respect bearing in mind the fact that the country is multi-religious and is susceptible to the influence of foreign cultures. As a way of using Islam to check the spread of the disease, this study calls for mass education, sexual discipline and avoidance of having contact with the blood of infected persons. To this end, Government is required to make adequate provisions for the health needs of citizens, get rid of quacks in medical and para-medical professions and make deliberate efforts to reduce poverty to the barest minimum if at all it cannot be totally eradicated. Economic stability will check the practice of taking chances with their health as they will be able to afford to settle their medical bills without any problem. Muslims, in particular and other religionists as well, are expected to live up to the moral teachings of their religion to lead a wholesome life free of disease.