Abstract: As much as developing states are blessed with natural resources capable of transforming their economies into a positive direction, the imposed World Trade Organisation’s (WTO) mores continue to relegate them to the status of underdevelopment. The consequences of this on investment, trade and finance in Third World States (TWSs), especially Africa are disarticulation of the economy, exploitation, disinvestment, unemployment, political instability and unavailability of relevant technology to move TWSs forward among others. The intention of this study is to situate the problems of biopiracy in Africa in terms of itsassociated western international regimes of Intellectual Propertyrights (IPRs), Geographical Indications (GIs), Prior Informed Consent (PIC) and Access and Sharing Benefits (ASB). This gives rise to the politics behind Rooibos (Aspalathus linearis) patenting (a medicinal plant found only in South Africa) by various Multinational Corporations (MNCs). The financial and economic transformations of Africa will be enhanced through a regional regime, African Regional Intellectual Property Organisation (ARIPO), on Indigenous Knowledge (IK) to patent the continental biodiversity resources.