Abstract: This study focuses on the relevance of the Simplified Trade Regime (STR) in addressing border protectionist measures that constraints the operations of small scale cross border traders at Chirundu One Stop Border Post (OSBP). The STR programme is an initiative of the Common Market for Eastern and Southern Africa (COMESA) and it is being implemented in the COMESA Region by the Member States. Zimbabwe as one of the COMESA State has signed the STR agreement with its neighbours, Zambia and Malawi and these agreements were facilitated by the COMESA Secretariat. The STR programme is meant to benefit the small scale cross border traders in several ways such as: employment creation, food security and promotion of cross pollination of goods within the COMESA Region. The major hypothesis underlying this study is: The COMESA Simplified Trade Regime is likely to provide remarkable solutions to the trade protectionist challenges faced by small scale cross border traders in their trading operations within the COMESA Region. The main objective guiding the study is: to discuss the impact of the COMESA STR in addressing trade protectionist challenges faced by small scale cross border traders. Researcher noted that there are few studies that outline the significance of STR in addressing trade protectionism, yet small scale cross border trade is fundamental for the development of Zimbabwe’s political economy. The study is centred on the liberalism theory. The study employed both qualitative and quantitative methodologies. The major recommendation derived from the study is that the Zimbabwean and Zambian governments should address protectionist challenges that are hindering the operations of small scale cross border traders at Chirundu OSBP and this could help to improve small scale cross border trade.