Abstract: The potential use of probiotics in restoring the urogenital and gastrointestinal health has received tremendous interest in the last decade, while few safety concerns are still being debated. Effect of oral administration of different doses of probiotic Lactobacillus casei 01 on the haematological parameters, serum protein and albumin of albino rats was investigated. Thirty two rats divided into four groups (A, B, C and D) of 8 rats per group were used. Group A was placed on the basal diet with pure milk alone, while group B, C and D were placed on the diet and also treated with 32, 64 and 96 mL of 107 cfu mL 1 of milk cultured of Lactobacillus casei 01, respectively for 45 days. Blood samples were collected by carotid artery cannulation for terminal bleeding into potassium EDTA containers. Parameters were determined using autohaematological analyzer. Results show there are significantly increase (p<0.01) in PDW, PMV and lymphocytes% by control group rats when compared to the other group rats. In rats treated with lowest doses of Lactobacillus casei 01 there were significantly increase (p<0.01) in Total protein, albumin, WBC and Mid amount when compared with the control, also amount of Granulocytes, HGB, RBC count and HCT in the highest dose group of Lactobacillus casei 01 are significantly highest (p<0.01) except RDW-CV that it was significantly increase (p<0.01) to the C group rats when compared with control group. In other parameter was not found meaningful different (p<0.05). The data obtained showed that milk fermented Lactobacillus casei 01 is safe and it has immunostimulatory effect. Its effect on haematological parameters was dose dependent.
Hamid Mirzaei , Bahram Amouoghli Tabrizi , Ali Hasanpour , Alireza Babapour and Guity Karim , 2008. Study on the Effect of Consuming Different Amount of Fermented Milk with Lactobacillus casei 01 on Haematological Parameters in Rats. Research Journal of Biological Sciences, 3: 1376-1380.