Authors : M. Moezizadeh and S. Moayedi
Abstract: The anticariogenic potential of casein phosphopeptid-amorphous calcium phosphate nanocomplexes (CPP-ACP) has been demonstrated using laboratory, animal and human in situ caries model. The CPP-ACP has also been shown to remineralize enamel subsurface lesions in vitro and in situ when delivered in sugar-free gum. The proposed anticariogenic mechanism for CPP-ACP is the localization of ACP at the tooth surface which buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel reducing demineralization and enhancing remineralization. The CPP-ACP therefore has exciting potential for use in oral care products and foods to help prevent dental caries and repair early stages of diseases, a development which will add significantly to dentists armoury of tools in preventive dentistry. This review article presents a brief on mechanism of action and role of CPP-ACP in caries prevention, remineralization of enamel lesions by CPP-ACP and use of CPP-ACP in different dental products like glass ionomer cement, tooth paste, mouth wash, tooth mousse and etc.
M. Moezizadeh and S. Moayedi , 2009. Anticariogenic Effect of Amorphous Calcium Phosphate Stabilized by Casein Phosphopeptid: A Review Article. Research Journal of Biological Sciences, 4: 132-136.