Authors : Parviz Padisar , Roya Nasseh , Mansour Khorasani and Marjan Nassiri Assl
Abstract: Since, pain is one of the most important reason that patient do not come for orthodontic treatments, pain control is important for both clinicians and patients. This double-blind prospective clinical trial was carried-out with the aim of determining the efficacy of common used Non-Steroidal Anti Inflammatory Drugs (NSAIDs). For pain control after orthodontic procedures. This study was carried-out in 2 stages. In the 1st stage, separators were placed on both sides of the 1st superior molar, in 43 patients (22 females and 21 males) to obtain their pattern of pain plotted on a 100 mm horizontal line (VAS). In the 2nd stage, 75 patients, after placement of initial arch wire, were randomly divided into 5 groups receiving 5 different treatments (Ibuprofen 400 mg, Naproxen 250 mg, Mefenamic Acid 250 mg, Aspirin 325 mg and placebo (Starch). After receiving 2 doses of drug (1 h before and 6 h after bonding), they indicated the severity of their pain during mastication, biting, fitting on anterior teeth and fitting on posterior teeth in different specified times. Statistical analyses were carried out based on ANOVA and t-test. The pain increased soon after placement of the arch wire and reached its peak in 24 h. In all cases, the least pain was reported following consumption of Ibuprofen and the most after taking placebo. There was no difference between molars and females in the reported severity of pain. The pattern of pain had no relation with gender and the pain began immediately after bonding and reached its peak in 24 h, then gradually decreased during a period of 7 days. Although, all NSAIDs were more or less effective in pain control ibuprofen was relatively more Effie in decreasing the pain.
Parviz Padisar , Roya Nasseh , Mansour Khorasani and Marjan Nassiri Assl , 2009. A Study on Efficacy of NSAIDs in Control of Pains Caused by Orthodontic. Research Journal of Biological Sciences, 4: 404-408.