Authors : Soheila Akbari , Sepideh Vahabi and Mojtatba Khaksarian
Abstract: Preeclampcia remains a major cause of prenatal morbidity and mortality worldwide. Cause of preeclampsia is still ill defined and there is no appropriate test for predicting occurrence of the disorder. This study aimed to assess association between preeclampsia and serum level of β-human chorionic gonadotropin (β-hCG). The study had cross-sectional design and carried out on 75 pregnant women admitted to Asalian hospital (Khorramabad/Iran) during 2004-2005. Subjects divided into 3 groups: Normotensive pregnancies, mild preeclampsia and severe preeclampsia. Then level of β-hCG was measured using Enzyme-linked Immunosorbent Assay (ELISA) method. The mean level of β-hCG was significantly higher (p<0.001) in severe preeclampsia (59220±4634 mIu mL-1) than normotensive and mild preeclamptic groups (18572±2123 mIu mL-1 and 23968± 6558, respectively). However, there was no significant difference between normotensive and mild preeclamptic groups regarding mean level of β-hCG (p>0.05). Our results showed that β-hCG may be a good indicator for severe preeclampsia but it is not suitable for early diagnosis of the disease. Performing more studies in this field is recommended to confirm this hypothesis.
Soheila Akbari , Sepideh Vahabi and Mojtatba Khaksarian , 2009. A Study of β-Human Chorionic Gonadotropin Level in Preeclamptic and Normotensive Pregnant Women. Research Journal of Biological Sciences, 4: 468-471.