Authors : B. M. Olabinri, O. O. Odedire, M. T Olaleye, A. S. Adekunle, L. O. Ehigie and P. F. Olabinri
Abstract: The hydroxyl and nitric oxide radical scavenging activities and total phenolic content of artemether were investigated in vitro. The concentrations of artemether (200-1000 μg mL-1) did not exhibit hydroxyl radical scavenging activity except at 200 μg mL-1 concentration. The mean values for the hydroxyl radical scavenging for the different concentration (200, 400, 600, 800 and 1000 μg mL-1) of artemether were 47.55±11.28, -3.49±13.16, -30.09±6.09, -34.74±4.29 and -49.00±7.75%, respectively. The total phenolic content of artemether in ethylacetate ranged from 208.00±48.33 (SD) to 340.00±14.14 μg mL-1, while the total phenolic content of artemether in methanol ranged from 90.00±6.3 (SD) to 122.00±35.44 μg mL-1. Total phenolic content of artemether was significantly higher in ethyl acetate than in methanol at all concentration investigated (p<0.05). The total phenolic content arthemeter was influenced by the organic solvent used as a medium for preparing artemether.
B. M. Olabinri, O. O. Odedire, M. T Olaleye, A. S. Adekunle, L. O. Ehigie and P. F. Olabinri, 2010. In vitro Evaluation of Hydroxyl and Nitric Oxide Radical Scavenging Activities of Artemether. Research Journal of Biological Sciences, 5: 102-105.