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Research Journal of Biological Sciences
Year: 2011 | Volume: 6 | Issue: 12 | Page No.: 632-634
DOI: 10.3923/rjbsci.2011.632.634  
Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives
Manmohan Singhal and Arindam Paul
 
Abstract: In the present study, researchers designed a Pharmacophore Model chalconesemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site, etc., using Ligandscout-2.02 software. A series of chalcone semicarbazones was synthesized and evaluated for their anti-fungal activity by Paper Disk Diffusion Method. Based on the results of an anti-fungal study, compound CS-10 was the most active compound. It was observed that methoxy substitution in aldehydic moiety and hydroxyl substitution in the acetophenic moiety significantly increased anti-microbial spectrum against fungi.
 
How to cite this article:
Manmohan Singhal and Arindam Paul, 2011. Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives. Research Journal of Biological Sciences, 6: 632-634.
DOI: 10.3923/rjbsci.2011.632.634
URL: http://medwelljournals.com/abstract/?doi=rjbsci.2011.632.634