Authors : F.B. Oyeyemi, S.A. Babajide, K.T. Elelu, W.A. Oyeyemi and O.A. Iyiola
Abstract: The biochemical and histological responses on liver of rats following feeding on unprocessed cassava was examined in this study. About 28 rats were randomly divided into four. Group A which served as the control was fed with 30 g of grower feed per day while groups B-D were given 10 g of unprocessed cassava and 20 g of grower feed per day, 20 g of unprocessed cassava and 10 g of grower feed per day and 30 g of unprocessed cassava per day, respectively. After feeding for 6 weeks, the animal weight, liver histology, Aspartate amino Transferase (AST), Alanine amino Transferase (ALT), Gamma Glutamyl Transpeptidase (GGT) and Alkaline Phosphatase (ALP) were measured. The result shows significant reduction in weight gain among groups B-D animals when compared with the control. Histological studies also revealed diffused hepatic degeneration of the liver in all treatments except the control; this damage is more evident in group D animals. There was a significant increase in ALP, AST, ALT and GGT activity in groups B-D when compared with the control group, the highest was observed in group D. Biochemical evidence of tissue injury in the liver was supported by histological findings of the liver which showed disturbance of normal hepatic cytoarchitecture on rats in groups B-D. It is concluded that feeding on unprocessed cassava is harmful to the liver.
F.B. Oyeyemi, S.A. Babajide, K.T. Elelu, W.A. Oyeyemi and O.A. Iyiola, 2012. Biochemical and Histological Responses on the Liver of Adult Wistar Rats Fed with Varied Level of Cassava. Research Journal of Biological Sciences, 7: 78-82.