Abstract: Dreams of having a child is a universal need and grief of infertility is considered as a great crisis in life. Lack of reproductive ability, attitude towards this problem and treating consideration is stressful while can cause serious psychological problems and severe negative effects on marital relationships. This study by regarding the significant prevalence of infertility and its psychological and economical burden on society has set itself, the objective of investigating the impact of infertility on psychosexual disorders in infertile women. In this study, 150 qualified infertile women were studied within 4 months. Data collection instruments in this study were three public health survey questionnaires SSQ, MSQ and GHQ for each patient. Collected data were analyzed using the SPSS software (16.5). Descriptive statistical procedures and ANOVA were employed. Results from this study indicated that 24.6% of the subjects had no evidence of depression, 30% symptoms of mild depression, 32% suffered from moderate depression and 13% had severe depressive symptoms. Spouse’s income and education level had significant correlation with the prevalence of depression. No significant relationship between age and anxiety and depression scores was found (p>0.05). Levels of life satisfaction in women was significantly low (p<0.05). Infertility diagnosis created a clear negative impact on women’s relationships with their husbands (p<0.05). Other than mechanism underlying depression, a series of specific risk factors associated with infertility problems in infertiles, can make infertile couples more prone to psychological problems. Reducing emotional common problems among infertile women and providing counseling services parallel to medical treatments in order to reduce these problems, is considered important.