Abstract: Zirab region of Mazandarn Province, located at Central-Northern Alborz mountain range of Iran includes numerous coal mines of vital importance for the regional economy. In the meantime, considerable precipitation, surface waters and relatively high level of the wells heightens the risk potential in the region. Rich underground and surface waters besides vast pastures and fertile agricultural lands have caused the people of the region to suitably welcome cultivation and breeding. Hence, considering the strategic importance of the mining in the region, an investigation was accomplished about the relationship between the livestock health from the one hand and coal extraction from the other. About 45 randomly taken blood samples 25 and 20 samples from Zirab and Alasht districts, respectively were gathered from among the flocks of the region without considering the age, gender, race, etc. The samples then were analyzed and assessed for cadmium-arsenic content and other toxic elements of the blood factors (CBC). Studies indicated that despite non-observation of the exploitation principles and discharge of the sewages into the environment, no unfavorable effect is seen among the livestock. The important result has been obtained from comparing the mentioned earlier said elements in 17 samples of agricultural soil, 26 samples of surface waters, 11 samples of the well waters and 9 samples of the mining wastes.